Colorado football is back at Folsom Field for its biggest test of the season.

The Buffaloes welcome No. 10 Texas Tech on Saturday evening, looking to pull off an improbable upset and snap a two-game losing streak. CU opened the season 2-0 before suffering consecutive Power Four losses to Northwestern and Baylor, with offensive struggles and self-inflicted issues the biggest concerns. The Buffs outgained both Baylor and Northwestern, but countless offensive drives stalled and kept points off the board.

Head coach Deion Sanders is set to make a change at quarterback, with Isaac Wilson taking over for Julian Lewis after Wilson sparked the Colorado offense when he came into the game at halftime last week. Defensively, Colorado needs its secondary to force Texas Tech quarterback Will Hammond into risky throws, which he is prone to do, leading the Big 12 with five interceptions.

Colorado has to play a near-perfect game to pull off an upset.

Follow along below for live updates, highlights and expert analysis throughout Colorado's Week 5 matchup with No. 10 Texas Tech at Folsom Field.

Colorado vs. No. 10 Texas Tech score

Colorado vs. Texas Tech live updates, analysis

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Refresh for the latest updates from Colorado's home game against Texas Tech.

Colorado vs. Texas Tech injury updates, inactives

06:15 PM ET, October 3 2026, Charlie Strella

  • Colorado — OUT: DB Makari Vickers, DB Jason Stokes Jr., WR Danny Scudero, DB Braylon Edwards, CB Preston Ashley, DL Lamont Lester Jr., TE Zach Atkins; GAME TIME DECISION: TE Charlie Williams
  • Texas Tech — OUT: QB Thomas Castellanos, CB Ashton Hampton, LB Adam Hill, OL Elias Gillen

The Buffs are officially down their top pass rusher, with Lamont Lester Jr. being downgraded to out. TE Charlie Williams is a game-time decision. His availability would be a big boost to the position, with Zach Atkins already ruled out.

Colorado vs. Texas Tech predictions, betting odds

06:05 PM ET, October 3 2026, Charlie Strella

Odds via BetMGM as of Saturday afternoon.

  • Texas Tech 28, Colorado 17: Texas Tech looked beatable against Sam Houston last week, but Colorado hasn't shown enough offensive firepower to make an upset believable. Isaac Wilson should help get the Go-Go offense moving, but the Buffs need to control the clock on the ground and capitalize on Will Hammond's turnover issues. If CU's defense can create short fields, Colorado can keep it close. Ultimately, Texas Tech is still too much for this version of the Buffs, but I don't expect a blowout. Here are our detailed staff predictions for the matchup.
  • Spread: Texas Tech by 14
  • Over/under: 49.5
  • Money line: Colorado +450, Texas Tech -600

Colorado vs. Texas Tech weather forecast

05:50 PM ET, October 3 2026, Charlie Strella

  • Forecasts for Saturday evening in Boulder call for a high of 82 degrees and a 0 % chance of rain. Mostly clear skies with a light wind.

How to watch Colorado vs. Texas Tech: TV channel, streaming info

05:35 PM ET, October 3 2026, Charlie Strella

  • Colorado vs. Texas Tech will air nationally on Fox in Week 5 of the 2026 college football season. Noah Reed and Devin Gardner will call the game from the booth at Folsom Field, with Josh Sims reporting from the sideline. Streaming options include the Fox Sports app and Fubo, which offers a free trial to new subscribers.
  • Date: Saturday, Oct. 3
  • Time: 5:30 p.m. MT

Watch Colorado vs. Texas Tech on Fox

This article originally appeared on Buffaloes Wire: Colorado vs. Texas Tech live updates: Score, highlights, analysis

Source: Yahoo Sports